Hydrogen chloride-ethyl acetate → 4-Cyclobutoxy-6-(piperazin-1-yl)pyrimidine dihydrochloride

HRID 1464955Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1464955
[CH:1]1([O:5][C:6]2[N:11]=[CH:10][N:9]=[C:8]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[CH:7]=2)[CH2:4][CH2:3][CH2:2]1.[ClH:25].CCOC(C)=O>CCOC(C)=O>[ClH:25].[ClH:25].[CH:1]1([O:5][C:6]2[CH:7]=[C:8]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[N:9]=[CH:10][N:11]=2)[CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66747845Tert-butyl 4-(6-cyclobutoxypyrimidin-4-yl)piperazine-1-carboxylate

Produkt 1

HCID 667473944-Cyclobutoxy-6-(piperazin-1-yl)pyrimidine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of tert-butyl 4-(6-cyclobutoxypyrimidin-4-yl)piperazine-1-carboxylate (687 mg, 2.06 mmol) and 4 M HCl-EtOAc (30 ml) were stirred at rt for 2 h. Then EtOAc was added, and the solvent was removed in vacuo. The residue was suspended in EtOAc, and the white precipitate was collected by filtration to give 525 mg (quant) of the title compound as a white solid. The compound was used for the next step without further purification.

Aufarbeitung

  1. customthe solvent was removed in vacuo
  2. filtrationthe white precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-a71444613f0f426181b450ba87fc8be5
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US08999974B2

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