Ammonia → 7-Bromothieno[3,2-d]pyrimidin-4-amine
Reaktionsgleichung
[Br:1][C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10](Cl)[C:5]=2[S:4][CH:3]=1.[NH3:12]>C(O)(C)C>[Br:1][C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10]([NH2:12])[C:5]=2[S:4][CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
7-Bromo-4-chlorothieno[3,2-d]pyrimidine (5 g, 20.17 mmol) obtained in Step 3 of Preparation Example 1 and 2.0M NH3 dissolved in isopropanol solution (50 mL) were added to a sealed reaction vessel and stirred at 100° C. for 12 hours. The reaction mixture was cooled to room temperature and filtered to obtain a solid. The solid was washed with water and dried with N2 gas to obtain the title compound (3.8 g, 83%) without further purification.
Aufarbeitung
- additionwere added to a sealed reaction vessel
- temperatureThe reaction mixture was cooled to room temperature
- filtrationfiltered
- customto obtain a solid
- washThe solid was washed with water
- dry with materialdried with N2 gas
Quellen und Nachweise
- ORD-Eintrag
- ord-ec173c7db495431682d8f1447eedaf48
- Quelldatensatz
- uspto-grants-2015_04
- Patentnummer
- US08999973B2
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