Methanol → Methyl 4-hydroxy-3-(trifluoromethyl)benzoate

HRID 1465007Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1465007
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[CH3:15]O>Cl>[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:15])=[O:7])=[CH:4][C:3]=1[C:11]([F:12])([F:13])[F:14]

Komponenten

4

Edukt 2

HCID 887MethanolHCID 27751124-Hydroxy-3-(trifluoromethyl)benzoic acid

Produkt 1

HCID 13962148Methyl 4-hydroxy-3-(trifluoromethyl)benzoateAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidKatalysator

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

4-Hydroxy-3-(trifluoromethyl)benzoic acid (2 g, 9.7 mmol) was dissolved in methanol (40 mL) and 12N HCl (10 drops) was added thereto. The reaction mixture was stirred at 90° C. for 48 hours, cooled to room temperature and concentrated, and then ethyl acetate (100 mL) was added thereto. The reaction mixture was washed with sat. NaHCO3 Solution, and the organic layer was dried with Na2SO4, filtered and concentrated to obtain the title compound (2.07 g, 91%) without further purification.

Aufarbeitung

  1. temperaturecooled to room temperature
  2. concentrationconcentrated
  3. additionethyl acetate (100 mL) was added
  4. washThe reaction mixture was washed with sat. NaHCO3 Solution
  5. dry with materialthe organic layer was dried with Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d60fe1c234d64b248cfd8b39081b3b7b
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US08999973B2

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