4-Methyl-3-nitroaniline → tert-Butyl (4-methyl-3-nitrophenyl)carbamate

HRID 1465027Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1465027
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12](=O)([OH:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15]>C1COCC1>[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Komponenten

4

Edukt 2

HCID 83904-Methyl-3-nitroanilineHCID 3015642Mono-tert-butyl carbonate

Produkt 1

HCID 18954623tert-Butyl (4-methyl-3-nitrophenyl)carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

4-Methyl-3-nitroaniline (5.0 g, 32.86 mmol) was dissolved in anhydrous THF (25 mL). t-Butyl bicarbonate (7.5 mL, 32.86 mmol) dissolved in anhydrous THF (25 mL) was added slowly to the reaction mixture, which was stirred at 65° C. for 18 hours. After the reaction was completed the remaining organic solvent was distilled under reduced pressure, and water was added thereto. The resulting yellow solid was filtered and dried to obtain the title compound without further purification.

Aufarbeitung

  1. additionwas added slowly to the reaction mixture, which
  2. distillationwas distilled under reduced pressure, and water
  3. additionwas added
  4. filtrationThe resulting yellow solid was filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d547698dd7ee4a56bca561fee49ee039
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US08999973B2

Notizen zur Reaktion

Wird geladen…