Thionyl Chloride → 4-Ethoxy-1-(4-fluorophenyl)pyrazole-3-carbonyl chloride

HRID 1465186Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1465186
[CH2:1]([O:3][C:4]1[C:5]([C:16]([OH:18])=O)=[N:6][N:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:8]=1)[CH3:2].S(Cl)([Cl:21])=O>>[CH2:1]([O:3][C:4]1[C:5]([C:16]([Cl:21])=[O:18])=[N:6][N:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:8]=1)[CH3:2]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 336766774-ethoxy-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid

Produkt 1

HCID 867081584-Ethoxy-1-(4-fluorophenyl)pyrazole-3-carbonyl chloride

Versuchsvorschrift

D3 (43 mg, 0.17 mmol, 1.0 eq.) was heated in thionyl chloride (1 mL) for 4 h at 67° C. Solvent was removed in vacuo and the crude material was resolved in dry toluene and evaporated under reduced pressure again to yield D4. The crude material was used in the next step without further purification.

Aufarbeitung

  1. customSolvent was removed in vacuo
  2. customevaporated under reduced pressure again

Quellen und Nachweise

ORD-Eintrag
ord-087e8d4a4f25427b845d58d767064a5c
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US08999982B2

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