Ethyl 2-(4-bromophenoxy)acetate → 2-(4-Bromophenoxy)acetamide

Reaktionsgleichung

CO.[NH3:3].[Br:4][C:5]1[CH:17]=[CH:16][C:8]([O:9][CH2:10][C:11](OCC)=[O:12])=[CH:7][CH:6]=1>>[Br:4][C:5]1[CH:17]=[CH:16][C:8]([O:9][CH2:10][C:11]([NH2:3])=[O:12])=[CH:7][CH:6]=1

Komponenten

Edukt 2

HCID 248825Ethyl 2-(4-bromophenoxy)acetate

HCID 21705897Ammonia methanol

Produkt 1

HCID 3028642-(4-Bromophenoxy)acetamideAusbeute 98 %

Versuchsvorschrift

7M-Ammonia methanol solution (10 ml, 70 mmol) was added to ethyl 2-(4-bromophenoxy)acetate (1.0 g, 3.86 mmol), and the mixture was stirred at room temperature for 2.5 hrs. The reaction mixture was concentrated under reduced pressure to give 2-(4-bromophenoxy)acetamide (870 mg, yield 98%) as a white solid.

Aufarbeitung

concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag: ord-0474a42cf25b40b6b4b1e58b784d031d
Quelldatensatz: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08999989B2

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