Thiourea → HCID 43141115, Verbindung

HRID 1465663Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1465663
Cl[CH2:2][C:3]([C:5]1[C:10]([F:11])=[CH:9][C:8]([F:12])=[CH:7][C:6]=1[F:13])=O.[NH2:14][C:15]([NH2:17])=[S:16]>CCO>[F:13][C:6]1[CH:7]=[C:8]([F:12])[CH:9]=[C:10]([F:11])[C:5]=1[C:3]1[N:14]=[C:15]([NH2:17])[S:16][CH:2]=1

Komponenten

4

Edukt 2

HCID 2723790ThioureaHCID 185218922-Chloro-1-(2,4,6-trifluorophenyl)ethan-1-one

Produkt 1

HCID 43141115HCID 43141115, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-chloro-1-(2,4,6-trifluorophenyl)ethanone (9.04 g, 43.5 mmol) and thiourea (3.51 g, 46.1 mmol) in 95% EtOH (50 mL) was heated at reflux overnight. The solution was concentrated and mixed with water (100 mL) and saturated aqueous Na2CO3 (5.0 mL). The solids were filtered and dried under vacuum to give 4-(2,4,6-trifluorophenyl)thiazol-2-amine (9.71 g) as pink-white solids in 97% yield: 1H NMR (500 MHz, DMSO-d6) δ 7.26-7.22 (m, 2 H), 7.09 (s, 2 H), 6.77 (s, 1 H).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationThe solution was concentrated
  4. additionmixed with water (100 mL) and saturated aqueous Na2CO3 (5.0 mL)
  5. filtrationThe solids were filtered
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e48bd4a6b4bf497798508c3ee0d0bfd3
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US08999983B2

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