4-(4-Bromophenyl)-4-hydroxypiperidine → 4-(4-Bromophenyl)-5,6-dihydropyridine

HRID 1466272Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1466272
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2(O)[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][N:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 1

HCID 939114-(4-Bromophenyl)-4-hydroxypiperidine

Produkt 1

HCID 667303604-(4-Bromophenyl)-5,6-dihydropyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of 4-(4-bromophenyl)piperidin-4-ol (500 mg, 1.95 mmol) in TFA (4 mL) was heated to 90° C. for 2 h. The crude reaction mixture was concentrated under reduced pressure to dryness, to give a yellow solid (460 mg, used without further purification). MS ESI 237.9 [M+H]+, calcd for [C11H12BrN+H]+ 238.02.

Aufarbeitung

  1. customThe crude reaction mixture
  2. concentrationwas concentrated under reduced pressure to dryness
  3. customto give
  4. customa yellow solid (460 mg, used without further purification)

Quellen und Nachweise

ORD-Eintrag
ord-a792a2cd9a144b528a7fab439b40997f
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US08999968B2

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