Imidazole → 5-Iodomethyl-2-phenyl-7-nitro-1H-indole

5-Hydroxymethyl-2-phenyl-7-nitro-1H-indole (804 mg, 3 mmol) prepared in Step A of Example 29 was dissolved in THF (10 mL), and imidazole (408 mg, 6 mmol) and triphenylphosphine (1.52 g, 6 mmol) were added thereto. Iodine (453 mg, 3.9 mmol) was added to the mixture, which was then stirred for 2 h. After completion of the reaction, the reaction mixture was filtered through a cellite, and the product was used in the next reaction without further purification.

1. customAfter completion of the reaction
2. filtrationthe reaction mixture was filtered through a cellite
3. customthe product was used in the next reaction without further purification

ORD-Eintrag

ord-168b1bbe6971435f8dc99c90b41bf3de

Quelldatensatz

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09000028B2