Trifluoroacetic acid → HCID 70496855, Verbindung

HRID 1466660Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1466660
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([O:41][CH3:42])=[C:13]([C:15]2[C:19]([NH:20][C:21]([C:23]3[C:31]4[N:30]=[CH:29][N:28]=[CH:27][C:26]=4[NH:25][N:24]=3)=[O:22])=[CH:18][N:17]([CH:32]([CH3:40])[C:33]([O:35]C(C)(C)C)=[O:34])[N:16]=2)[CH:14]=1>ClCCl>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([O:41][CH3:42])=[C:13]([C:15]2[C:19]([NH:20][C:21]([C:23]3[C:31]4[N:30]=[CH:29][N:28]=[CH:27][C:26]=4[NH:25][N:24]=3)=[O:22])=[CH:18][N:17]([CH:32]([CH3:40])[C:33]([OH:35])=[O:34])[N:16]=2)[CH:14]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 70495258HCID 70495258, Verbindung

Produkt 1

HCID 70496855HCID 70496855, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (10 mL) was added dropwise to a solution of tert-butyl 2-(3-(5-chloro-2-methoxyphenyl)-4-(pyrazolo pyrimidine-3-carboxamido)-1H-pyrazol-1-yl)propanoate (0.945 g, 1.90 mmol, 1 equiv) in dichloromethane (10 mL). After 2 h, the reaction mixture was concentrated in vacuo to afford crude product (quantitative) which was used without further purification. LCMS (ESI): M+H=441.1.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customto afford crude product (quantitative) which
  3. customwas used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-eaea4760c2cf4f3cabb180e67fa33f74
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US08999998B2

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