Ethanol → Ethyl 3-bromo-4-methoxybenzoate

HRID 1466813Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1466813
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6].OS(O)(=O)=O.[CH3:18][CH2:19]O>>[CH2:18]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:2]([Br:1])[CH:3]=1)[CH3:19]

Komponenten

4

Edukt 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 668363-Bromo-4-methoxybenzoic acid

Produkt 1

HCID 23062539Ethyl 3-bromo-4-methoxybenzoate

Versuchsvorschrift

3-Bromo-4-methoxy-benzoic acid (2.5 g, 11.6 mmol) was dissolved in EtOH (20 mL) and conc. H2SO4 (1 mL) was added. The reaction was heated to reflux overnight then submitted to standard aqueous workup. The residue was purified by silica gel chromatography (0-50% EtOAc in hexanes) to yield the title compound.

Aufarbeitung

  1. temperatureThe reaction was heated
  2. temperatureto reflux overnight
  3. customThe residue was purified by silica gel chromatography (0-50% EtOAc in hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-93cd1783997c4f829e87d3da859135cd
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09000025B2

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