Chloroacetone → HCID 66764943, Verbindung

HRID 1466816Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1466816
[CH2:1]([O:3][C:4](=[O:14])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([SH:13])[CH:6]=1)[CH3:2].C(N(CC)CC)C.Cl[CH2:23][C:24](=[O:26])[CH3:25].CCOC(C)=O>C1COCC1>[CH2:1]([O:3][C:4](=[O:14])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([S:13][CH2:23][C:24](=[O:26])[CH3:25])[CH:6]=1)[CH3:2]

Komponenten

6

Edukt 4

HCID 6571ChloroacetoneHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 66764668HCID 66764668, Verbindung

Produkt 1

HCID 66764943HCID 66764943, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3-Mercapto-4-methoxy-benzoic acid ethyl ester (1.29 g, 6.08 mmol) and triethylamine (2.12 mL, 15.19 mmol) were dissolved in THF (20 mL) at 0° C. Chloroacetone (0.58 mL, 7.29 mmol) was then added and the reaction stirred at room temperature for 30 minutes. It was then allowed to slowly warm to room temperature and stirred an additional 30 minutes. Standard aqueous workup followed by silica gel chromatography (0-70% EtOAc in hexanes) gave the title compound.

Aufarbeitung

  1. temperatureto slowly warm to room temperature
  2. stirringstirred an additional 30 minutes

Quellen und Nachweise

ORD-Eintrag
ord-3720f8e87e0343edb07455a2d4f8fa81
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09000025B2

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