3-Fluoro-5-(4-methoxy-benzylsulfanyl)-benzoic acid ethyl ester → 3-Fluoro-5-mercapto-benzoic acid ethyl ester
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:22])[C:5]1[CH:10]=[C:9]([S:11]CC2C=CC(OC)=CC=2)[CH:8]=[C:7]([F:21])[CH:6]=1)[CH3:2]>C(O)(C(F)(F)F)=O>[CH2:1]([O:3][C:4](=[O:22])[C:5]1[CH:10]=[C:9]([SH:11])[CH:8]=[C:7]([F:21])[CH:6]=1)[CH3:2]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
3-Fluoro-5-(4-methoxy-benzylsulfanyl)-benzoic acid ethyl ester (7.24 g, 22.5 mmol)was stirred in TFA (10 mL) at 70° C. for overnight. The resulting mixture was cooled to room temperature and subjected to standard aqueous workup. The crude residue was purified on silica gel (0-30% EtOAc in hexanes) to afford the title compound.
Aufarbeitung
- customThe crude residue was purified on silica gel (0-30% EtOAc in hexanes)
Quellen und Nachweise
- ORD-Eintrag
- ord-fb6a0a8e1ddf406087c3bb1518feae61
- Quelldatensatz
- uspto-grants-2015_04
- Patentnummer
- US09000025B2
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