4-Bromo-1-isopropyl-1H-pyrazole → 3-[6-Chloro-7-fluoro-1-(1-isopropyl-1H-pyrazol-4-yl)-2-methyl-1H-indol-3-ylsulfanyl]-5-fluoro-benzoic acid ethyl ester
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:25])[C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([S:12][C:13]2[C:21]3[C:16](=[C:17]([F:23])[C:18]([Cl:22])=[CH:19][CH:20]=3)[NH:15][C:14]=2[CH3:24])[CH:6]=1)[CH3:2].Br[C:27]1[CH:28]=[N:29][N:30]([CH:32]([CH3:34])[CH3:33])[CH:31]=1>>[CH2:1]([O:3][C:4](=[O:25])[C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([S:12][C:13]2[C:21]3[C:16](=[C:17]([F:23])[C:18]([Cl:22])=[CH:19][CH:20]=3)[N:15]([C:27]3[CH:28]=[N:29][N:30]([CH:32]([CH3:34])[CH3:33])[CH:31]=3)[C:14]=2[CH3:24])[CH:6]=1)[CH3:2]Komponenten
3
Versuchsvorschrift
Prepared according to the procedure described in Example 55, Step 2 using the following starting materials: 3-(6-Chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-5-fluoro-benzoic acid ethyl ester and 4-bromo-1-isopropyl-1H-pyrazole.
Aufarbeitung
- customPrepared