Hydrochloric Acid → HCID 66745948, Verbindung

HRID 1467186Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1467186
[CH:1]([NH:4][C:5]1[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-])=O)[C:6]=1[C:7]#[N:8])([CH3:3])[CH3:2].Cl>CO.[Fe]>[NH2:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:5]([NH:4][CH:1]([CH3:3])[CH3:2])[C:6]=1[C:7]#[N:8]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 574159382-Nitro-6-[(propan-2-yl)amino]benzonitrile

Produkt 1

HCID 66745948HCID 66745948, VerbindungAusbeute 106,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a solution of 2-(isopropylamino)-6-nitrobenzonitrile (Example 157c) (0.21 g, 1.02 mmol) in MeOH (9 mL) was added concentrated HCl (2 mL). Then Fe (0.17 g, 3.07 mmol) was added portionwise, and the reaction mixture was refluxed at 90° C. for 15 minutes. After cooling to room temperature, dilution with H2O (50 mL) and extraction with DCM (3×50 mL), the combined organic phases were washed with brine, dried over MgSO4 and the solvents were evaporated to give 2-amino-6-(isopropylamino)benzonitrile (0.19 g, 100%) as a brown oil which was used in the next step without any further purification. MS 176 (MH+).

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. extractiondilution with H2O (50 mL) and extraction with DCM (3×50 mL)
  3. washthe combined organic phases were washed with brine
  4. dry with materialdried over MgSO4
  5. customthe solvents were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-cf44a84b2b8a46cc9d329188424ad73e
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09000054B2

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