5-(Methylsulfonyl)-1H-indole → tert-Butyl 4-((6-(5-(methylsulfonyl)-1H-indol-1-yl)pyridin-3-yl)amino)-piperidine-1-carboxylate

HRID 1467981

Reaktionsgleichung

Reaktionsgleichung von HRID 1467981
Br[C:2]1[N:7]=[CH:6][C:5]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH3:22][S:23]([C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][CH:30]=[CH:29]2)(=[O:25])=[O:24]>>[CH3:22][S:23]([C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[N:31]([C:2]1[N:7]=[CH:6][C:5]([NH:8][CH:9]3[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]3)=[CH:4][CH:3]=1)[CH:30]=[CH:29]2)(=[O:25])=[O:24]

Komponenten

3

Edukt 2

HCID 149732305-(Methylsulfonyl)-1H-indoleHCID 86602140Tert-butyl 4-((6-bromopyridin-3-yl)amino)piperidine-1-carboxylate

Produkt 1

HCID 86696183tert-Butyl 4-((6-(5-(methylsulfonyl)-1H-indol-1-yl)pyridin-3-yl)amino)-piperidine-1-carboxylate

Versuchsvorschrift

The title compound was prepared by following the similar procedure as described in Intermediate-27 using tert-butyl 4-((6-bromopyridin-3-yl)amino)piperidine-1-carboxylate and 5-(methylsulfonyl)-1H-indole; MS: 415.2 (M−56).

Quellen und Nachweise

ORD-Eintrag
ord-b8a86f90f42c496eb92448d37fa76720
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09000175B2

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