5-(Methanesulfonyl)-2,3-dihydro-1H-indole → tert-Butyl-4-(4-(5-(methylsulfonyl)indolin-1-yl)phenoxy)piperidine-1-carboxylate

HRID 1468013

Reaktionsgleichung

Reaktionsgleichung von HRID 1468013
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18](Br)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:22][S:23]([C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][CH2:30][CH2:29]2)(=[O:25])=[O:24]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N:31]3[C:32]4[C:28](=[CH:27][C:26]([S:23]([CH3:22])(=[O:25])=[O:24])=[CH:34][CH:33]=4)[CH2:29][CH2:30]3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 27361365-(Methanesulfonyl)-2,3-dihydro-1H-indoleHCID 467390061-BOC-4-(4-bromophenoxy)piperidine

Produkt 1

HCID 67608798tert-Butyl-4-(4-(5-(methylsulfonyl)indolin-1-yl)phenoxy)piperidine-1-carboxylate

Versuchsvorschrift

The title compound was prepared by following the similar procedure as described in Intermediate-27 using tert-butyl-4-(4-bromophenoxy)piperidine-1-carboxylate and 5-(methylsulfonyl)indoline (0.11 g, 35%); MS: 373 (M−100).

Quellen und Nachweise

ORD-Eintrag
ord-4d6807a380ac49bb82f1befc55ad4d2a
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09000175B2

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