3-[4-(4-Cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid methyl ester → 3-[4-(4-Cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid

HRID 1468177Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1468177
C[O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][N:11]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=3)[CH:13]=[N:12]2)[CH:5]=1>CO.O>[C:22]([C:19]1[CH:18]=[CH:17][C:16]([C:14]2[CH:13]=[N:12][N:11]([CH2:10][C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[C:3]([OH:24])=[O:2])[CH:15]=2)=[CH:21][CH:20]=1)#[N:23]

Komponenten

3

Edukt 1

HCID 675085333-[4-(4-Cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid methyl ester

Produkt 1

HCID 675082023-[4-(4-Cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acidAusbeute 82,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22242641Methanol--water (1/1)Lösungsmittel

Versuchsvorschrift

Add LiOH monohydrate (0.03 g, 0.8 mmol) to a suspension of 3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid methyl ester (0.2 g, 0.6 mmol) in 5 mL of a 4:1 MeOH-water mixture and stir the reaction at room temperature overnight. Concentrate the reaction to remove most of the MeOH, dilute with additional H2O and neutralize by the addition of 1 N aqueous HCl. Isolate the resulting solid by filtration and dry to afford 0.15 g, 71% yield of 3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid.

Aufarbeitung

  1. customthe reaction at room temperature overnight
  2. concentrationConcentrate
  3. customthe reaction
  4. customto remove most of the MeOH
  5. additiondilute with additional H2O and neutralize by the addition of 1 N aqueous HCl
  6. customIsolate the resulting solid
  7. filtrationby filtration
  8. customdry

Quellen und Nachweise

ORD-Eintrag
ord-e61d724ed5f14b7782df7400fb053c02
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09000154B2

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