Hydrochloric Acid → 2-(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-N-methyl-N-pyridin-3-ylmethyl-acetamide hydrochloride

HRID 14684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 14684
C(OC(=O)[NH:7][CH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[C:16]([O:19][CH3:20])[CH:17]=2)[C:12]([CH2:23][C:24](=[O:34])[N:25]([CH3:33])[CH2:26][C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)=[CH:11][N:10]=1)(C)(C)C.[ClH:36]>CCOC(C)=O>[ClH:36].[NH2:7][CH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:21][CH3:22])=[C:16]([O:19][CH3:20])[CH:17]=2)[C:12]([CH2:23][C:24]([N:25]([CH3:33])[CH2:26][C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)=[O:34])=[CH:11][N:10]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 68613824{6,7-Dimethoxy-4-[(methyl-pyridin-3-ylmethyl-carbamoyl)-methyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester

Produkt 1

HCID 686134592-(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-N-methyl-N-pyridin-3-ylmethyl-acetamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

As described in Example 1, {6,7-dimethoxy-4-[(methyl-pyridin-3-ylmethyl-carbamoyl)-methyl]-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 2-(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-N-methyl-N-pyridin-3-ylmethyl-acetamide hydrochloride. MS: APCI (M+H) calc'd for C21H24N4O3+H 381.4; found 381.1.

Quellen und Nachweise

ORD-Eintrag
ord-4479118baaee4f79bbd06a719d03699a
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732446B1

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