SK&F 81297 → Dopamine

HRID 1468604

Reaktionsgleichung

Reaktionsgleichung von HRID 1468604
CCCN1[C@@H]2CC3C4C(=CC=CC=4NC=3)[C@H]2C[C@@H](CSC)C1.C1[C:33]2[C:28](=[CH:29][C:30]([OH:36])=[C:31]([OH:35])[C:32]=2Cl)[CH:27](C2C=CC=CC=2)[CH2:26][NH:25]C1>>[NH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([OH:35])=[C:30]([OH:36])[CH:29]=1

Komponenten

3

Edukt 2

HCID 1218SK&F 81297HCID 47811Pergolide

Produkt 1

HCID 681Dopamine

Versuchsvorschrift

HEK cells were transfected with a DNA construct encoding D1-NLS-GFP (1.5 micrograms of DNA), and incubated with the agonist pergolide (10 micromolar) for 48 hours. At 6, 22, 30 and 42 hours after transfection, the cells were treated with fresh medium containing SKF-81297 (final concentration 10 micromolar). The cells were examined by confocal microscopy.

Aufarbeitung

  1. additionAt 6, 22, 30 and 42 hours after transfection, the cells were treated with fresh medium

Quellen und Nachweise

ORD-Eintrag
ord-eafaf474af62467882714ab53dff96ee
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09005905B2

Verknüpfte Notizen

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