(4-Methanesulfonylphenyl)methanol → 5-isopropyl-2-{4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidin-1-yl}pyrimidine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	(4-Methanesulfonylphenyl)methanol	HCID 3801026	—
Edukt	{(1R,2R)-2-[1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}methanol	HCID 71128800	—
Edukt	2-{4-[(1R,2R)-2-(iodomethyl)cyclopropyl]piperidin-1-yl}-5-isopropylpyrimidine	HCID 86717787	—
Produkt	5-isopropyl-2-{4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidin-1-yl}pyrimidine	HCID 71128804	—

Reaktionsschritte

Using the procedure outlined in intermediate 8 (step B) the product from step C was reacted with 4-(methylsulfonyl)benzyl alcohol to yield the title compound. MS (ESI) m/z 444 [M+H]+. GPR119 Human EC50: 0.26 nM

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09006228B2
Quelldatensatz	uspto-grants-2015_04
ORD ID	ord-d0e9665830b04af08dd3e5b763fbca13
Quellennotiz	uspto-grants-2015_04