Cesium carbonate → 5-Bromo-2-chloro-3-(4-propoxybenzyl)thiophene

To a solution of phenol 4 (500 mg, 1.65 mmol) in acetone (25 mL) were added 1-iodopropane (0.5 mL, 4.95 mmol) and Cs2CO3 (460 mg, 4.95 mmol) at room temperature. The mixture was stirred at 60° C. for 12 hours. The reaction mixture was cooled to room temperature and filtered off through celite. The filtrate was concentrated in vacuo. The residue was purified by silica column chromatography (Biotage) to provide the title compound 5 (600 mg, 99%).

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationfiltered off through celite
3. concentrationThe filtrate was concentrated in vacuo
4. customThe residue was purified by silica column chromatography (Biotage)

ORD-Eintrag

ord-958801c9981e4be9b26bf2dc402475e9

Quelldatensatz

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09006187B2