Sulfuric Acid → 7-Iodoisatin

HRID 1470637Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1470637
ON=[CH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[I:13])=[O:5].[OH:14]S(O)(=O)=O>>[I:13][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:7]=1[NH:6][C:4](=[O:5])[C:3]2=[O:14]

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 63998232-(Hydroxyimino)-N-(2-iodophenyl)acetamide

Produkt 1

HCID 40437057-IodoisatinAusbeute 87 %

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

2-(hydroxyimino)-N-(2-iodophenyl)acetamide (3.2 g, 0.011 mmol) was added to conc. H2SO4 (15 mL) in small portions at 60° C. The reaction mixture was further heated at 85° C. for 5 h. After the reaction completion, the reaction mixture was cooled to room temperature and poured into crushed ice. A brown color solid product precipitated. It was then filtered and washed with chilled water several times, then dried in a vacuum oven to get 2.9 g of the required product as a red coloured solid (87%).

Aufarbeitung

  1. temperatureAfter the reaction completion, the reaction mixture was cooled to room temperature
  2. additionpoured
  3. custominto crushed ice
  4. customA brown color solid product precipitated
  5. filtrationIt was then filtered
  6. washwashed with chilled water several times
  7. customdried in a vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-1b14c10ffc9f42068fb6b542d51a8c66
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09006454B2

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