4-Fluoroaniline → 1-(4-Fluorophenyl)-2,5-bis(4-nitrophenyl)-1H-pyrrole

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-Fluoroaniline	HCID 9731	—
Edukt	1,4-Bis(4-nitrophenyl)butane-1,4-dione	HCID 13762891	—
Lösungsmittel	Acetic Acid	HCID 176	—
Lösungsmittel	Water	HCID 962	—
Lösungsmittel	Diethyl Ether	HCID 3283	—
Produkt	1-(4-Fluorophenyl)-2,5-bis(4-nitrophenyl)-1H-pyrrole	HCID 58226815	91%

Reaktionsbedingungen

Temperatur	70 °C

Reaktionsschritte

To a slurry of the product from Example 1A (1.5 g, 4.57 mmol) in acetic acid (22.85 mL) was S added 4-fluoroaniline (4.33 ml, 45.7 mmol). The mixture was heated to 70° C. for 24 h. After cooling to rt the mixture was diluted with water and ether and stirred vigorously, filtered and dried to provide 1.67 g (91%) of the title compound.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09006387B2
Quelldatensatz	uspto-grants-2015_04
ORD ID	ord-8facd0a73fe4459ba68272f5b9cce00d
Quellennotiz	uspto-grants-2015_04