Hydrochloric Acid → (S)-Pyrrolidine-2-carboxamide monohydrochloride

HRID 1470991Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1470991
[C:1]([C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1C(OC(C)(C)C)=O)(=[O:3])[NH2:2].[ClH:16].O1CCOCC1>>[ClH:16].[NH:5]1[CH2:6][CH2:7][CH2:8][C@H:4]1[C:1]([NH2:2])=[O:3]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 7019053tert-butyl (S)-2-carbamoylpyrrolidine-1-carboxylate

Produkt 1

HCID 12707183(S)-Pyrrolidine-2-carboxamide monohydrochlorideAusbeute 104 %

Versuchsvorschrift

To (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate (29.8 g, 139 mmol) was added a solution of 4N HCl in dioxane (209 mL, 836 mmol) and the resultant mixture stirred at room temperature for 18 hrs. The mixture was then concentrated and triturated with diethyl ether then vacuum filtered and dried under vacuum to provide 21.6 g (104%) of the title product as a colorless solid.

Aufarbeitung

  1. concentrationThe mixture was then concentrated
  2. customtriturated with diethyl ether
  3. filtrationvacuum filtered
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-21d156fea55d4e6396955523ce73d32a
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09006387B2

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