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Tetrafluoro-m-phenylenediamine dihydrochloride → Tetrafluoro-m-phenylenediamine dihydrochloride

HRID 1472494
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1472494
[C:1]1([NH2:12])[C:6]([F:7])=[C:5]([F:8])[C:4]([F:9])=[C:3]([NH2:10])[C:2]=1[F:11].[ClH:13].Cl.[F:15][C:16]1[CH:17]=[C:18]([N:28]2[CH2:32][CH:31]([CH2:33][NH:34]C(C3C=CC=CC=3)C)[O:30][C:29]2=[O:43])[CH:19]=[CH:20][C:21]=1[N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>[OH-].[OH-].[Pd+2].CO>[C:1]1([NH2:12])[C:6]([F:7])=[C:5]([F:8])[C:4]([F:9])=[C:3]([NH2:10])[C:2]=1[F:11].[ClH:13].[ClH:13].[F:15][C:16]1[CH:17]=[C:18]([N:28]2[CH2:32][CH:31]([CH2:33][NH2:34])[O:30][C:29]2=[O:43])[CH:19]=[CH:20][C:21]=1[N:22]1[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 2

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 902170523-(3-Fluoro-4-morpholinylphenyl)-5-[(1-phenylethyl)aminomethyl]-1,3-oxazolidin-2-one

Produkt 2

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 227145793-Fluoro-4-morpholinylphenyl-5-aminomethyl-1,3-oxazolidin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167
Palladium hydroxide
Katalysator
HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a reaction flask were added 3.0 g of dihydrochloride of 3-(3-fluoro-4-morpholinylphenyl)-5-[(1-phenylethyl)aminomethyl]-1,3-oxazolidin-2-one (4a), 100 ml of methanol and 1.0 g of 10% Pd(OH)2/C. Gas inside the reaction flask was evacuated and argon was then introduced to the reaction flask. The reaction mixture was allowed to react for 48 hours at room temperature with stirring. After the reaction was completed, the reaction mixture was filtered, and subsequently put under reduced pressure for solvent removal to give a dihydrochloride of 3-(3-fluoro-4-morpholinylphenyl-5-aminomethyl-1,3-oxazolidin-2-one (5a) as a white solid and at a yield of 95%.

Aufarbeitung

  1. customGas inside the reaction flask was evacuated
  2. additionargon was then introduced to the reaction flask
  3. customto react for 48 hours at room temperature
  4. filtrationthe reaction mixture was filtered
  5. customsubsequently put under reduced pressure for solvent removal

Quellen und Nachweise

ORD-Eintrag
ord-09781232b5914341b4f1c078021fd588
Quelldatensatz
uspto-grants-2015_04
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US09012631B2

Notizen zur Reaktion

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