Sodium Hydroxide → Sodium 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate

HRID 1473302Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1473302
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:9]=2[CH:10]=[CH:11][C:12]([S:18]([O:21]CC(F)(F)F)(=[O:20])=[O:19])=[CH:13]3)=[C:4]([O:27][CH3:28])[CH:3]=1.[OH-].[Na+:30]>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:9]=2[CH:10]=[CH:11][C:12]([S:18]([O-:21])(=[O:19])=[O:20])=[CH:13]3)=[C:4]([O:27][CH3:28])[CH:3]=1.[Na+:30]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 866873582,2,2-Trifluoroethyl 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate

Produkt 1

HCID 86687359Sodium 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonateAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A round bottomed flask was charged with 2,2,2-trifluoroethyl 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate (1.729 g, 4.01 mmol) and CH2Cl2 (8.03 mL). Sodium hydroxide (2M in MeOH) (4.01 mL, 8.03 mmol) was added at rt. The solution was capped and maintained at rt for 18 h resulting in a white precipitate. The white solid was collected by vacuum filtration, rinsing with diethyl ether to yield sodium 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate (1.481 g, 3.99 mmol) as a fluffy white solid. The solid was used directly without further purification.

Aufarbeitung

  1. customThe solution was capped
  2. customresulting in a white precipitate
  3. filtrationThe white solid was collected by vacuum filtration
  4. washrinsing with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-d91bc7b42bd946f3b2675a89d9ce6d67
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09012443B2

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