Trifluoroacetic acid → HCID 86678431, Verbindung

HRID 1473718Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1473718
C(OC([NH:8][C@@H:9]([CH2:17][CH2:18][CH:19]([CH2:23][CH2:24][CH2:25][F:26])[C:20]([OH:22])=[O:21])[C:10]([O:12]C(C)(C)C)=[O:11])=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:8][C@@H:9]([CH2:17][CH2:18][CH:19]([CH2:23][CH2:24][CH2:25][F:26])[C:20]([O-:22])=[O:21])[C:10]([OH:12])=[O:11].[NH4+:8]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86678430HCID 86678430, Verbindung

Produkt 1

HCID 86678431HCID 86678431, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 1-tert-Butyl 6-hydrogen (2S)-2-[(tert-butoxycarbonyl)amino]-5-(3-fluoropropyl)-hexanedioate (57.0 mg, 0.15 mmol) and trifluoroacetic acid (0.5 mL) and dichloromethane (0.5 mL) was stirred at r.t. for 30 min. Then the mixture was concentrated under reduced pressure and the residue was purified by preparative HPLC (ZIC HILIC, 5 μm 100×4.6 mm, acetonitrile/0.1 M aqueous ammonium formate solution gradient, 10 mL/min).

Aufarbeitung

  1. concentrationThen the mixture was concentrated under reduced pressure
  2. customthe residue was purified by preparative HPLC (ZIC HILIC, 5 μm 100×4.6 mm, acetonitrile/0.1 M aqueous ammonium formate solution gradient, 10 mL/min)

Quellen und Nachweise

ORD-Eintrag
ord-ff2856ec28f247b1be4d2534fe0048a4
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09017645B2

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