Hydrochloric Acid → 2-Hydroxy-4-(thiazol-2-ylamino)benzonitrile
Reaktionsgleichung
Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[NH2:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([OH:16])[CH:9]=1.Cl>CCO>[OH:16][C:10]1[CH:9]=[C:8]([NH:7][C:2]2[S:3][CH:4]=[CH:5][N:6]=2)[CH:15]=[CH:14][C:11]=1[C:12]#[N:13]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 90 °C
Versuchsvorschrift
Following the general procedure for the synthesis of 2-R-5-(thiazol-2-ylamino)phenol, 2-bromothiazole (0.94 mL, 10.4 mmol), 4-amino-2-hydroxybenzonitrile (696 mg, 5.2 mmol) and 37% HCl solution (0.88 mL, 10.4 mmol) in 10% aqueous EtOH solution (20 mL) was stirred at 90° C. for 24 h. The title compound was obtained after purification by flash chromatography on silica gel (hexane:EtOAc 1/1) in 26% yield (293 mg).
Quellen und Nachweise
- ORD-Eintrag
- ord-4ca5e91211b64ea198f44c5d7bbfaee2
- Quelldatensatz
- uspto-grants-2015_04
- Patentnummer
- US09018209B2
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