3-Bromo-2,5-dimethylbenzoic acid → (3-bromo-2,5-dimethylphenyl)methanol

HRID 1474322Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1474322
[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5](O)=[O:6]>C1COCC1>[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH2:5][OH:6])[CH:8]=[C:9]([CH3:11])[CH:10]=1

Komponenten

3

Edukt 1

HCID 592382453-Bromo-2,5-dimethylbenzoic acid

Produkt 1

HCID 10656303(3-bromo-2,5-dimethylphenyl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 3-bromo-2,5-dimethylbenzoic acid (3.5 g, 15 mmol) in anhydrous THF was added borane THF complex (1.0 M, 25 mL, 25 mmol) at 0, then the reaction was warmed to ambient temperature overnight. The reaction was quenched with MeOH and concentrated to afford (3-bromo-2,5-dimethylphenyl)methanol.

Aufarbeitung

  1. customThe reaction was quenched with MeOH
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-7493043f55034c139b232a4efd223ef5
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09018211B2

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