4,7-Difluoro-2,3-dihydro-1H-inden-1-amine → HCID 117736897, Verbindung

HRID 1474576Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1474576
[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH2:12].[C:13]([O:17][C:18]([N-:20][S:21](N1C=CC(=[N+](C)C)C=C1)(=[O:23])=[O:22])=[O:19])([CH3:16])([CH3:15])[CH3:14]>C(Cl)Cl.CCOC(C)=O.Cl>[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH:12][S:21]([NH:20][C:18](=[O:19])[O:17][C:13]([CH3:15])([CH3:14])[CH3:16])(=[O:22])=[O:23]

Komponenten

6

Edukt 2

HCID 584399044,7-Difluoro-2,3-dihydro-1H-inden-1-amineHCID 178482962HCID 178482962, Verbindung

Produkt 1

HCID 117736897HCID 117736897, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 313Hydrochloric AcidLösungsmittelHCID 6344DichloromethaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 4,7-difluoro-2,3-dihydro-1H-inden-1-amine (CAS No. 625471-13-8, 1.19 g, 11.2 mmol) in DCM (50 mL) were added [(tert-Butoxy)carbonyl]{[4-(dimethyliminio)pyridin-1(4H)-yl]sulfonyl}amide (3.70 g, 12.3 mmol) and TEA (4.66 mL, 33.5 mmol) at room temperature. The resulting solution was stirred for 75 hours at room temperature. The reaction mixture was diluted with AcOEt and 1N HCl and the layers were separated. The organic layer was dried over anhydrous Na2SO4 and evaporated in vacuo to afford the title compound (3.82 g, 11.0 mmol).

Aufarbeitung

  1. customthe layers were separated
  2. dry with materialThe organic layer was dried over anhydrous Na2SO4
  3. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9d3a9702ac064e4abd005287323ba8e3
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09018260B2

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