Ammonia → 3-Methyl-1H-1,2,4-triazole-5-carboxamide

HRID 1475221Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1475221
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([O:9]CC)=O)[N:3]=1.[NH3:12]>CO>[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([NH2:12])=[O:9])[N:3]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 10464537ethyl 3-methyl-1H-1,2,4-triazole-5-carboxylate

Produkt 1

HCID 122201083-Methyl-1H-1,2,4-triazole-5-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate (3.0 g, 19.3 mmol) is placed in a sealed tube that is then charged with a solution of 7N NH3 in MeOH (40 mL). The reaction is stirred at 50° C. for 24 h. The solvent was then removed under reduced pressure and the crude material was used directly for the next step without further purification. MS (ES+) C4H6N4O requires: 126. found: 127 [M+H]+.

Aufarbeitung

  1. customThe solvent was then removed under reduced pressure
  2. customthe crude material was used directly for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-a9f6569fffba48f9b1af211c473f4130
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09018380B2

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