HCID 70981446, Verbindung → HCID 86724015, Verbindung
Reaktionsgleichung
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:18]3[O:22][N:21]=[C:20]([CH3:23])[N:19]=3)=[C:14]([Cl:17])[CH:15]=2)[C:10]([CH3:25])([CH3:24])[CH2:9]1)=O)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[Cl:17][C:14]1[CH:15]=[C:16]2[C:11]([C:10]([CH3:24])([CH3:25])[CH2:9][NH:8]2)=[CH:12][C:13]=1[C:18]1[O:22][N:21]=[C:20]([CH3:23])[N:19]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
6-Chloro-3,3-dimethyl-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (36 mg, 0.11 mmol) was dissolved in 50% TFA in DCM (0.534 mL) and the mixture was stirred for 30 minutes and concentrated. The residue was dissolved in methanol, loaded onto an SCX column and eluted with methanol then 2.0M ammonia in methanol to release the amine and fractions concentrated, to give the title compound (26 mg), MS: [M+H]+=264.