Ammonia methanol → 7-Chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxamide

HRID 1476818Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1476818
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:13]([O:15]CC)=O)[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[NH3:18].CO>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:13]([NH2:18])=[O:15])[NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 21705897Ammonia methanolHCID 90386855Ethyl 7-chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxylate

Produkt 1

HCID 903871057-Chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxamideAusbeute 38 %

Versuchsvorschrift

Ethyl 7-chloro-1-oxo-1,2-dihydroisoquinoline-3-carboxylate (580 mg, 2.30 mmol) was dissolved in NH3/MeOH(4.0M, 15 mL) and the reaction mixture was stirred at RT overnight. The solvent was removed in vacuo. The resulting residue was washed with petroleum ether and dried to give the title compound (200 mg, 38%). ESI-MS m/z [M+H]+223.1.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. washThe resulting residue was washed with petroleum ether
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e9268d116d794627aca07daa61a2164a
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09402841B2

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