Trifluoroacetic acid → 6-Chloro-4-iodo-N-methylpyridin-3-amine

HRID 1477272Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1477272
C(O[C:6](=O)[N:7]([C:9]1[CH:10]=[N:11][C:12]([Cl:16])=[CH:13][C:14]=1[I:15])C)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:16][C:12]1[N:11]=[CH:10][C:9]([NH:7][CH3:6])=[C:14]([I:15])[CH:13]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 57443399Tert-butyl (6-chloro-4-iodopyridin-3-yl)(methyl)carbamate

Produkt 1

HCID 574434006-Chloro-4-iodo-N-methylpyridin-3-amineAusbeute 97,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To the solution of tert-butyl(6-chloro-4-iodopyridin-3-yl)(methyl)carbamate (62.5 g, 0.172 mol) in 500 mL of anhydrous DCM was added 180 mL of TFA. Then the solution was stirred at room temperature for 4 hrs. Concentrated to remove the solvent, and purified by flash chromatography to afford 45.1 g 6-chloro-4-iodo-N-methylpyridin-3-amine as a yellow solid (Yield: 97.3%).

Aufarbeitung

  1. concentrationConcentrated
  2. customto remove the solvent
  3. custompurified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-375a4e5a667e439bb5934451cf611187
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09403772B2

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