HCID 86688408, Verbindung → HCID 86688407, Verbindung
Reaktionsgleichung
[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH:13]C(=O)C2C=CC=CC=2)=[S:12])[N:7]([CH2:22][CH3:23])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]>[OH-].[Na+]>[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH2:13])=[S:12])[N:7]([CH2:22][CH3:23])[N:6]=1)([CH3:4])([CH3:2])[CH3:3]Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 90 °C
Versuchsvorschrift
A suspension of compound 24 (5 g, 15.1 mmol) in 30 mL of 5% NaOH aqueous solution was stirred in an oil bath of 90° C. for 8 hrs and cooled down to room temperature. Ice was added while stirring to the reaction mixture. The resulting suspension was filtered, and the cake was washed with cold water (10 mL×3) and further dried in vacuo to afford the desired product 8 as an off-white powder.