HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Leucinamide hydrochloride → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Leucinamide hydrochloride | HCID 2733199 | — |
| Edukt | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid | HCID 86682331 | — |
| Produkt | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide | HCID 71525763 | — |
Reaktionsschritte
The title compound was synthesized in analogy to Example 6, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g) and (2S)-2-amino-4-methyl-pentanamide hydrochloride (1:1) (CAN 10466-61-2) as starting materials, and isolated (46 mg, 62%) as light yellow gum; LC-MS (UV peak area, ESI) 100%, 347.2081 (M+H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09403808B2 |
| Quelldatensatz | uspto-grants-2016_08 |
| ORD ID | ord-1e57a45542a34008bd4b17c43bd54d73 |
| Quellennotiz | uspto-grants-2016_08 |