Hydrochloride methanol → Methyl 3-(4-amino-1H-indol-1-yl)-3-(4-chlorophenyl)pentanoate

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Reaktionsgleichung

C(OC([NH:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[CH:12][N:13]2[C:18]([C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=1)([CH2:27][CH3:28])[CH2:19][C:20]([O:22][C:23](C)(C)C)=[O:21])=O)(C)(C)C.Cl.CO>>[NH2:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[CH:12][N:13]2[C:18]([C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=1)([CH2:27][CH3:28])[CH2:19][C:20]([O:22][CH3:23])=[O:21]

Komponenten

Edukt 2

HCID 21893726Hydrochloride methanol

HCID 117809455tert-Butyl 3-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-3-(4-chlorophenyl)pentanoate

Produkt 1

HCID 68175795Methyl 3-(4-amino-1H-indol-1-yl)-3-(4-chlorophenyl)pentanoate

Versuchsvorschrift

A mixture of the product of Step F (120 mg, 0.24 mmol) and 4 N HCl/MeOH (2 mL) was stirred at room temperature for 2 h. The volatile was removed in vacuo to give the title compound as colorless oil. LC/MS m/z=357.1[M+H]+.

Aufarbeitung

customThe volatile was removed in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-671273ccfb4b4d6a85cc3f534a19a44a
Quelldatensatz: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09403807B2

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