HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trimethyl orthoformate → 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trimethyl orthoformate | HCID 9005 | — |
| Edukt | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Edukt | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | — |
| Produkt | 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine | HCID 86603261 | — |
Reaktionsschritte
Intermediate 1 (3.69 g) was refluxed for two hours in trimethylorthoformate containing 10 mL of 4N HCl/dioxane. The solvent was removed by rotary evaporation to give product, which showed the expected M+H+ of 265 by LC-MS.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07732444B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-7533bb8fdece41aa9e7946c5e94b613b |
| Quellennotiz | uspto-grants-2010_06 |