Hydrochloric Acid → 3-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzaldehyde

HRID 14785

Reaktionsgleichung

Reaktionsgleichung von HRID 14785
C[O:2][CH:3](OC)[C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([NH:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=3)[N:11]=2)[CH:7]=[CH:8][CH:9]=1.Cl>CC#N>[OH:25][C:22]1[CH:21]=[CH:20][C:19]([CH2:18][CH2:17][NH:16][C:12]2[N:11]=[C:10]([C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[CH:3]=[O:2])[CH:15]=[CH:14][N:13]=2)=[CH:24][CH:23]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 670450574-{2-[4-(3-Dimethoxymethyl-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol

Produkt 1

HCID 866032623-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Intermediate 27 (2.2 g) was treated with 30 mL of 3N HCl in 60 mL of CH3CN at room temperature overnight. The solvent was removed by rotary evaporation and the residue partitioned between ethyl acetate/sat. NaHCO3. Yield: 1.9 g, 99%. LC-MS showed the product had the expected M+H+ of 320.

Aufarbeitung

  1. customThe solvent was removed by rotary evaporation
  2. customthe residue partitioned between ethyl acetate/

Quellen und Nachweise

ORD-Eintrag
ord-35af2987e5d84ed19c3e51c6c0d54461
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732444B2

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