(2S)-N-methoxy-N-methyloxolane-2-carboxamide → 1-[(2S)-tetrahydrofuran-2-yl]but-3-en-1-one
Reaktionsgleichung
CON(C)[C:4]([C@@H:6]1[CH2:10][CH2:9][CH2:8][O:7]1)=[O:5].[CH3:12][C@@H:13]1C[C@H:14]1C(=O)CC=C>>[O:7]1[CH2:8][CH2:9][CH2:10][C@H:6]1[C:4](=[O:5])[CH2:14][CH:13]=[CH2:12]Komponenten
3
Versuchsvorschrift
(2S)—N-Methoxy-N-methyltetrahydrofuran-2-carboxamide (C92) was converted to the product using the method described for the synthesis of 1-[(1R,2R)-2-methylcyclopropyl]but-3-en-1-one (C80) in Example 20. The resulting product was used in the next step without further purification. Yield: 19 g, ≦0.14 mol, ≦87%.
Aufarbeitung
- customThe resulting product was used in the next step without further purification
Quellen und Nachweise
- ORD-Eintrag
- ord-07bac94c87574982b8c0db993f8dc7dd
- Quelldatensatz
- uspto-grants-2016_08
- Patentnummer
- US09403846B2
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