Ethyl trifluoroacetate → N-(4-Hydroxybutyl)trifluoroacetamide
Reaktionsgleichung
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][OH:6].C([O:9][C:10](=O)[C:11]([F:14])([F:13])[F:12])C>C(O)C>[F:12][C:11]([F:14])([F:13])[C:10]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][OH:6])=[O:9]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution (100 ml) of 4-aminobutanol (2.50 g, 28.05 mmol) and trifluoroacetic acid ethyl ester (19.92 g, 140.26 mmol) in ethanol was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure to give 4-trifluoroacetamidobutanol (11) (5.44 g, q.) as a colorless syrup.
Aufarbeitung
- concentrationThe reaction mixture was concentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-379d547febd8476ca601119fa0fcb783
- Quelldatensatz
- uspto-grants-2016_08
- Patentnummer
- US09404108B2
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