Acetyl chloride → N-(5,6-dichloropyridin-3-yl)acetamide

HRID 1479556Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1479556
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:9])[CH:5]=[N:6][C:7]=1[Cl:8].C(N(CC)CC)C.[C:17](Cl)(=[O:19])[CH3:18]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:17](=[O:19])[CH3:18])[CH:5]=[N:6][C:7]=1[Cl:8]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 145952195-Amino-2,3-dichloropyridine

Produkt 1

HCID 86652352N-(5,6-dichloropyridin-3-yl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of 5,6-dichloropyridin-3-amine (commercially available) and triethyl amine (3 eq) in CH2Cl2 (0.2 M) at 0° C. was added acetyl chloride (2 eq). After stirring at room temperature overnight the reaction mixture was concentrated under vacuum and the resulting crude residue was purified by chromatography (silica gel, 20-50% EtOAc in hexanes) to afford N-(5,6-dichloropyridin-3-yl)acetamide.

Aufarbeitung

  1. concentrationwas concentrated under vacuum
  2. customthe resulting crude residue was purified by chromatography (silica gel, 20-50% EtOAc in hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-70c462645a8a4d75bb5b8101918567f6
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09408907B2

Notizen zur Reaktion

Wird geladen…