1-Aminocyclopentanemethanol → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxymethyl-cyclopentyl)-amide

HRID 1480043

Reaktionsgleichung

[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][C:17]1([CH2:22][OH:23])[CH2:21][CH2:20][CH2:19][CH2:18]1>>[OH:23][CH2:22][C:17]1([NH:16][C:8]([C:5]2[CH:4]=[C:3]([O:11][CH2:12][CH:13]3[CH2:15][CH2:14]3)[C:2]([Cl:1])=[CH:7][N:6]=2)=[O:10])[CH2:21][CH2:20][CH2:19][CH2:18]1

Komponenten

Edukt 2

HCID 663071-Aminocyclopentanemethanol

HCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Produkt 1

HCID 762824855-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxymethyl-cyclopentyl)-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and 1-amino-cyclopentanemethanol (CAN 10316-79-7) as starting materials and isolated (40 mg, quant.) as white solid; MS (ESI, m/z): 325.1 (MH+).

Aufarbeitung

customisolated (40 mg, quant.) as white solid

Quellen und Nachweise

ORD-Eintrag: ord-69c70462415b4063b38eb9850b0debd2
Quelldatensatz: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09409866B2

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