(S)-2,2,2-Trifluoro-1-(pyridin-3-YL)ethanamine hydrochloride → 5-Chloro-4-(4-fluoro-benzyloxy)-pyridine-2-carboxylic acid ((S)-2,2,2-trifluoro-1-pyridin-3-yl-ethyl)-amide

HRID 1480085Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1480085
[Cl:1][C:2]1[C:3]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.Cl.[F:21][C:22]([F:32])([F:31])[C@H:23]([C:25]1[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=1)[NH2:24]>>[F:32][C:22]([F:21])([F:31])[C@@H:23]([NH:24][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[C:25]1[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=1

Komponenten

3

Edukt 2

HCID 51358484(S)-2,2,2-Trifluoro-1-(pyridin-3-YL)ethanamine hydrochlorideHCID 902035625-Chloro-4-(4-fluoro-benzyloxy)-pyridine-2-carboxylic acid

Produkt 1

HCID 762827235-Chloro-4-(4-fluoro-benzyloxy)-pyridine-2-carboxylic acid ((S)-2,2,2-trifluoro-1-pyridin-3-yl-ethyl)-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 12d, using 5-chloro-4-(4-fluoro-benzyloxy)-pyridine-2-carboxylic acid and (αS)-α-(trifluoromethyl)-3-pyridinemethanamine hydrochloride (1:1) (CAN 749839-26-7) as starting materials and isolated (26 mg, 83%) as colorless oil; MS (ESI, m/z): 440.3 (MH+).

Aufarbeitung

  1. customisolated (26 mg, 83%) as colorless oil

Quellen und Nachweise

ORD-Eintrag
ord-d7fa0cfa06714077bb324cd9af0cb1d1
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409866B2

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