1-Cyclopropyl-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethan-1-amine → 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid [1-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

HRID 1480102

Reaktionsgleichung

Reaktionsgleichung von HRID 1480102
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH:19]1([C:22]([NH2:30])([C:24]2[N:28]=[C:27]([CH3:29])[O:26][N:25]=2)[CH3:23])[CH2:21][CH2:20]1>>[CH:19]1([C:22]([NH:30][C:10]([C:7]2[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]3[CH2:2][CH2:3]3)=[CH:9][N:8]=2)=[O:12])([C:24]2[N:28]=[C:27]([CH3:29])[O:26][N:25]=2)[CH3:23])[CH2:21][CH2:20]1

Komponenten

3

Edukt 2

HCID 435592231-Cyclopropyl-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethan-1-amineHCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Produkt 1

HCID 762829675-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid [1-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 24d, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 1-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (CAN 1155536-64-3) as starting materials and isolated (190 mg, 27%) as alight yellow oil; MS (ESI, m/z): 411.0 (M+H+).

Aufarbeitung

  1. customisolated (190 mg, 27%) as alight yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-d436c413f19f4673825b0cffbc87a67d
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409866B2

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