Hydrochloric Acid → 3,5-Dichlorobenzyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate hydrochloride

HRID 1480456Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1480456
[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[C:26]([Cl:28])[CH:27]=1)[CH2:5][O:6][C:7]([NH:9][CH:10]1[CH2:16][CH:15]2[N:17](C(OC(C)(C)C)=O)[CH:12]([CH2:13][CH2:14]2)[CH2:11]1)=[O:8].Cl>O1CCOCC1>[ClH:1].[CH:15]12[NH:17][CH:12]([CH2:13][CH2:14]1)[CH2:11][CH:10]([NH:9][C:7](=[O:8])[O:6][CH2:5][C:4]1[CH:3]=[C:2]([Cl:1])[CH:27]=[C:26]([Cl:28])[CH:25]=1)[CH2:16]2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86722680HCID 86722680, Verbindung

Produkt 1

HCID 867226813,5-Dichlorobenzyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

A reaction mixture comprising of tert-butyl 3-((((3,5-dichlorobenzyl)oxy)carbonyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate (388.3 mg, 0.904 mmol) in dioxane (5 mL) was treated with 4M HCl in dioxane (0.678 mL, 2.71 mmol) and stirred at room temperature for 3 hours. The resulting mixture concentrated under reduced pressure. No further purification was carried out and the material was taken on crude to the next step.

Aufarbeitung

  1. concentrationThe resulting mixture concentrated under reduced pressure
  2. customNo further purification

Quellen und Nachweise

ORD-Eintrag
ord-a7d1343e8cb847c39d82b31d49a4bb99
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409895B2

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