Thionyl Chloride → HCID 178521140, Verbindung

HRID 1480460Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1480460
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=O)[N:3]=[N:2]1.S(Cl)([Cl:14])=O>C(Cl)Cl>[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][C:9]([Cl:14])=[O:11])[N:3]=[N:2]1

Komponenten

4

Edukt 2

HCID 24386Thionyl Chloride2×HCID 178525383HCID 178525383, Verbindung

Produkt 1

HCID 178521140HCID 178521140, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution/suspension of 4-(1H-1,2,3-triazol-4-yl)butanoic acid (150 mg, 0.967 mmol) in dry DCM (10 mL) was added thionyl chloride (0.847 mL, 11.60 mmol) at RT. After 30 mins some solid still remained so a further 0.4 ml thionyl chloride was added and the reaction mixture allowed to stir at RT for 2 hrs. The reaction mixture was concentrated under reduced pressure to afford the title product which was used in the next step without further purification.

Aufarbeitung

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d9d9817ae2ec4bafa63d006f8796184c
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409895B2

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