Thionyl Chloride → HCID 178521140, Verbindung

HRID 1480480Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1480480
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=O)[N:3]=[N:2]1.S(Cl)([Cl:14])=O>C(Cl)Cl>[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][C:9]([Cl:14])=[O:11])[N:3]=[N:2]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 178525383HCID 178525383, Verbindung

Produkt 1

HCID 178521140HCID 178521140, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred suspension of 4-(1H-1,2,3-triazol-4-yl)butanoic acid (Example 17, step 4) (0.088 g, 0.57 mmol) in DCM (5 mL) at RT under nitrogen was added thionyl chloride (0.499 mL, 6.84 mmol) and the reaction mixture stirred at RT for 2 hours. The reaction mixture was concentrated under reduced pressure to afford the crude title product.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-44dcd45add1445998e76ddb6bf129943
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409895B2

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