Piperidine → (2S)-4-amino-2-(((tert-butoxy)carbonyl)amino)butanoic acid

HRID 1481020Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1481020
[NH:1]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C@H:2]([C:23]([OH:25])=[O:24])[CH2:3][CH2:4][NH:5]C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.N1CCCCC1>CN(C=O)C>[NH2:5][CH2:4][CH2:3][C@H:2]([NH:1][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C:23]([OH:25])=[O:24]

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 2755945Boc-Dab(Fmoc)-OH

Produkt 1

HCID 7019666(2S)-4-amino-2-(((tert-butoxy)carbonyl)amino)butanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Boc-L-Dab(Fmoc)-OH (132 mg, 0.3 mmol, PepTech) and piperidine (0.2 mL, 2.02 mmol) were dissolved in DMF (1 mL). The resulting mixture was stirred at room temperature for 30 minutes. The volatiles were removed in vacuo and the residue was used directly in the subsequent step without further purification.

Aufarbeitung

  1. customThe volatiles were removed in vacuo
  2. customthe residue was used directly in the subsequent step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-e6a05d0cb9c749679e54cfa24643962d
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409892B2

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